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  • 标题:Expression of Bone Morphogenetic Proteins, Cartilage-Derived Morphogenetic Proteins and Related Receptors in Normal and Osteoarthritic Human Articular Cartilage
  • 本地全文:下载
  • 作者:Bobinac, Dragica ; Španjol, Josip ; Marinović, Marin
  • 期刊名称:Collegium Antropologicum
  • 印刷版ISSN:0350-6134
  • 出版年度:2008
  • 卷号:32 - Supplement 2
  • 期号:2
  • 页码:83-87
  • 出版社:Hrvatsko antropološko društvo
  • 摘要:Newborn and adult articular cartilage expresses bone (BMPs) and cartilage derived morphogenetic proteins (CDMPs). These morphogenetic proteins act over membrane receptors (BMPRs). We examined the expression pattern of BMP-7, BMP-3, CDMP-1, CDMP-2 and their receptors in adult normal and osteoarthritic, articular, knee cartilage. Immunostaining was carried out using polyclonal antibodies. The expression of BMP-7,-3, CDMP-1,-2 was detected in all layers of normal articular cartilage with the strongest expression in chondrocytes of the transitional layer. BMP-7 and CDMPs expression decreased in osteoarthritic articular cartilage whereas BMP-3 expression was absent. BMPR-IA and BMPR-II were strongly expressed in both normal and osteoarthritic articular cartilage. BMPR-IB was not expressed in osteoarthritic (OA) cartilage. BMPs and CDMPs with intact signalling play an important role in articular cartilage homeostasis, preventing cartilage degeneration.
  • 关键词:articular cartilage; bone morphogenetic proteins; cartilage derived morphogenetic proteins; osteoarthritis
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