文章基本信息

标题：Association of Two Genetic Variations of Lipoprotein Lipase, S447X and Hind III, with Coronary Artery Disease and Hypertriglyceridemia
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作者：Pašalić, Daria ; Ferenčak, Goran ; Gršković, Branka 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2006
卷号：30
期号：3
页码：549-555
出版社：Hrvatsko antropološko društvo
摘要：This study was performed to assess the effect of the S447X and Hind III lipoprotein lipase gene polymorphisms on development of coronary artery disease and hypertriglyceridemia. The study included 132 patients and 98 healthy control subjects of Croatian descent. The lipoprotein lipase S447X polymorphism was associated with coronary artery disease and hypertriglyceridemia, as indicated by the lower frequency of S447 allele in the patient group (p=0.005) and odds ratio (O.R=0.40, p=0.006). The patient and control groups also showed a significant difference in the distribution of Hind III/S447X genotype combinations (p=0.013). There were no significant associations with lipid parameters for any genotype or genotype combination in the patient group. Frequencies of the S447X polymorphism and S447X/Hind III combinations differed between the CAD/TG and control group, thus these polymorphisms may be associated with CAD and hypertriglyceridemia.
关键词：coronary artery disease; hypertriglyceridemia; lipoprotein lipase; polymorphism; Croatia