文章基本信息

标题：Serum Concentration of Zinc, Copper, Manganese and Magnesium in Patients with Liver Cirrhosis
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作者：Rahelić, Dario ; Kujundžić, Milan ; Romić, Željko 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2006
卷号：30
期号：3
页码：523-528
出版社：Hrvatsko antropološko društvo
摘要：The role of trace elements in the pathogenesis of liver cirrhosis and its complications is still not clearly understood. Serum concentrations of zinc, copper, manganese and magnesium were determined in 105 patients with alcoholic liver cirrhosis and 50 healthy subjects by means of plasma sequential spectrophotometer. Serum concentrations of zinc were significantly lower (median 0.82 vs. 11.22 mol/L, p Serum concentrations of copper were significantly higher in patients with liver cirrhosis (median 21.56 vs. 13.09 mol/L, p different between patients with liver cirrhosis and controls (0.94 vs. 0.88 mmol/L, p=0.132). There were no differences in the concentrations of zinc, copper, manganese and magnesium between male and female patients with liver cirrhosis. Only manganese concentration was significantly different between Child-Pugh groups (p=0.036). Zinc concentration was significantly lower in patients with hepatic encephalopathy in comparison to cirrhotic patients without encephalopathy (0.54 vs. 0.96 mol/L, p=0.002). The correction of trace elements concentrations might have a beneficial effect on complications and maybe progression of liver cirrhosis. It would be recommendable to provide analysis of trace elements as a routine.
关键词：zinc; copper; manganese; magnesium; liver cirrhosis; trace elements