文章基本信息

标题：Ovarian Cancer: PCD and Brain Metastases
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作者：Stepanić, Vesna ; Matković, Višnja ; Ćorušić, Ante 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2007
卷号：31
期号：2
页码：633-636
出版社：Hrvatsko antropološko društvo
摘要：Paraneoplastic cerebellar degeneration (PCD), the one of the most common paraneoplastic syndromes, refer to clinical disorders associated mostly with lung, ovarian and breast cancer, but not directly caused by the cancer or its metastases. Pathologic finding is an extensive loss of Purkinje cells in the cerebellum. Immunohistocemicaly, the auto-antibodies on the Purkinje cells had been detected. Clinically, PCD is characterized by sub-acutely evolving pancerebellar symptoms. Neurological dysfunction may appear before the detection of the underlying cancer. Therefore, the surgical exploration is necessary for the final diagnosis. The patient undergoes specific therapy. Soon, neurological status of the patient gets irreparable worse. Death come usually 2–3 years after the first symptoms of the PCD occurs. Case of a 63-years old woman with PCD as the first evidence of her cancer is reported. The patient developed brain metastases and died almost 3 years after the first symptoms of PCD occur.
关键词：auto-antibodies; brain metastases; gynecologic malignancies; paraneoplastic syndromes