文章基本信息

标题：Possible Prognostic Significance of P53 and Ki 67 in Inverted Sinonasal Papilloma
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作者：Bura, Miljenko ; Seiwerth, Sven ; Vladika, Ivan 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2007
卷号：31
期号：2
页码：545-549
出版社：Hrvatsko antropološko društvo
摘要：The aim of this study is to test the possible prognostic significance of p53 and Ki67 expression in inverted papilloma of the lateral nasal wall and adjacent sinuses regarding their malignant potential and recurrence. 49 biopsies of the lateral nasal wall and adjacent sinuses obtained from 41 patients from three hospitals were investigated. Immunohistochemically demonstrated p53 and Ki67 expression was measured and statistically valuated. p53 immunoreactivity was demonstrated in most of papillomas with carcinomas but only in two benign papillomas, while Ki67 demonstrated stronger immunoreactivity in carcinomas and surrounding epithelium. Immunohistochemical staining of inverted sinonasal papillomas for p53 and Ki67 can give useful information concerning the existence of synchronous carcinoma and, in case of high Ki67, a hint toward possible recurrence.
关键词：head and neck tumors; nasal tumors; inverted papilloma; prognostic factors; Ki67; p53