文章基本信息

标题：Intravitreal Bevacizumab (Avastin) in Treatment of Neovascular Age-related Macular Degeneration
本地全文：下载
作者：Lazić, Ratimir ; Gabrić, Nikica ; Dekaris, Iva 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2007
卷号：31 - Supplement 1
期号：1
页码：315-319
出版社：Hrvatsko antropološko društvo
摘要：To evaluate the efficacy and safety of intravitreal bevacizumab in treatment of minimally classic and occult choroidal neovascularization secondary to age-related macular disease 48 eyes of 48 patients (mean age of 74.8) included in this prospective, noncomparative, interventional case series. Median follow-up was 18 weeks (6–24). Intravitreal bevacizumab injection of 0.05 mL (1.25 mg) was administered at baseline and in 6 week intervals until leakage resolved, and repeated in case of leakage recurrence. Visual acuity (VA) improved in the majority of patients (mean baseline VA=1.078 log MAR) by mean increase of 1.32 lines (last follow-up) (p=0.001). Central foveal thickness and total macular volume decreased by 51 μm (p=0.01) and 0.84 mm3 (p therapy, intravitreal bevacizumab appears to be safe and effective. A significant functional and anatomical improvement was noted in majority of patients and maintained during follow-up.
关键词：bevacizumab; ranibizumab; pegaptanib