文章基本信息

标题：Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling
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作者：Christian D. Sadik ; Nancy D. Kim ; Yoichiro Iwakura 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2012
卷号：109
期号：46
页码：E3177-E3185
DOI：10.1073/pnas.1213797109
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Neutrophil recruitment into the joint is a hallmark of inflammatory arthritides, including rheumatoid arthritis (RA). In a mouse model of autoantibody-induced inflammatory arthritis, neutrophils infiltrate the joint via multiple chemoattractant receptors, including the leukotriene B4 (LTB4) receptor BLT1 and the chemokine receptors CCR1 and CXCR2. Once in the joint, neutrophils perpetuate their own recruitment by releasing LTB4 and IL-1{beta