文章基本信息

标题：Human Excretion of Bisphenol A: Blood, Urine, and Sweat (BUS) Study
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作者：Stephen J. Genuis ; Sanjay Beesoon ; Detlef Birkholz 等
期刊名称：Journal of Environmental and Public Health
印刷版ISSN：1687-9805
电子版ISSN：1687-9813
出版年度：2012
卷号：2012
DOI：10.1155/2012/185731
出版社：Hindawi Publishing Corporation
摘要：Background. Bisphenol A (BPA) is an ubiquitous chemical contaminant that has recently been associated with adverse effects on human health. There is incomplete understanding of BPA toxicokinetics, and there are no established interventions to eliminate this compound from the human body. Using 20 study participants, this study was designed to assess the relative concentration of BPA in three body fluids—blood, urine, and sweat—and to determine whether induced sweating may be a therapeutic intervention with potential to facilitate elimination of this compound. Methods. Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with assorted health problems) and analyzed for various environmental toxicants including BPA. Results. BPA was found to differing degrees in each of blood, urine, and sweat. In 16 of 20 participants, BPA was identified in sweat, even in some individuals with no BPA detected in their serum or urine samples. Conclusions. Biomonitoring of BPA through blood and/or urine testing may underestimate the total body burden of this potential toxicant. Sweat analysis should be considered as an additional method for monitoring bioaccumulation of BPA in humans. Induced sweating appears to be a potential method for elimination of BPA.