文章基本信息

标题：Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses
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作者：Rika Ouchida ; Hiromi Mori ; Koji Hase 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2012
卷号：109
期号：40
页码：E2699-E2706
DOI：10.1073/pnas.1210706109
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：IgM antibodies have been known for decades to enhance humoral immune responses in an antigen-specific fashion. This enhancement has been thought to be dependent on complement activation by IgM-antigen complexes; however, recent genetic studies render this mechanism unlikely. Here, we describe a likely alternative explanation; mice lacking the recently identified Fc receptor for IgM (FcR) on B cells produced significantly less antibody to protein antigen during both primary and memory responses. This immune deficiency was accompanied by impaired germinal center formation and decreased plasma and memory B-cell generation. FcR did not affect steady-state B-cell survival but specifically enhanced the survival and proliferation induced by B-cell receptor cross-linking. Moreover, FcR-deficient mice produced far more autoantibodies than control mice as they aged, suggesting that FcR is also required for maintaining tolerance to self-antigens. Our results thus define a unique pathway mediated by the FcR for regulating immunity and tolerance and suggest that IgM antibodies promote humoral immune responses to foreign antigen yet suppress autoantibody production through at least two pathways: complement activation and FcR.
关键词：B-cell activation ; autoimmune disease ; complement receptor