This paper discusses inter-ethnic contacts and ethonogenetic processes in lower Banat. This part of the Danube region attracted various nations (the Dacians, Romans, Celts, Avars, Slavs, Hungarians, Romanians, Germans) from ancient times. From the 18th century, one could follow the cultural influences of western Europe which came with the settled Germans. After World War II, the Serbs, Macedonians, Moslems were settled there instead of the emigrated Germans. Thus the inter-ethnic contacts of different nations continued further on. Still, in this part of Banat, from Middle Ages the basic ethnic characteristics have been related to the Serbs.