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  • 标题:Correlation between 24-hour profile of blood pressure and ventricular arrhythmias and their prognostic significance in patients with arterial hypertension
  • 本地全文:下载
  • 作者:Đorđević Dragan ; Deljanin-Ilić Marina ; Tasić Ivan
  • 期刊名称:Vojnosanitetski pregled
  • 印刷版ISSN:0042-8450
  • 出版年度:2008
  • 卷号:65
  • 期号:5
  • 页码:353-358
  • DOI:10.2298/VSP0805353D
  • 出版社:Military Medical Academy, INI
  • 摘要:

    Background/Aim. Left ventricular hypertrophy (LVH), apart from arterial hypertension, is a risk factor for electrophysiologic heart condition disorder and sudden cardiac death. The aim of this study was to examine a relationship between complex ventricular arrhythmias and parameters of 24-hour ambulatory blood pressure monitoring in the patients with arterial hypertension and left ventricular hypertrophy (LVH), as well as their prognostic significance during a five-year follow-up. Methods. Ninety patients with arterial hypertension and LVH were included in this study (mean age 55.2±8.3 years). There were 35 healthy people in the control group (mean age 54.5±7.1 years). Left ventricular mass index was 171.9±32.4 g/m2 in the LVH group and 102.4±13.3 g/m2 in the control group. Clinical examination, echocardiogram, 24-hour ambulatory blood pressure monitoring and 24-hour holter monitoring were done in all of the examined persons. Ventricular arrhythmias were classified by the Lown classification. Results. In the LVH group there were 54 (60.0%) of the patients with ≥ III Lown class. The best predictor of a Lown class were left ventricular mass index by using multivariate stepwise regression analyses (β = 0.212; p < 0.05) and small decrease of diastolic blood pressure during the night (β = -0.293; p < 0.01). The main predictor of bad prognosis was left ventricular mass index during a five year follow-up (β = 0.302; p < 0.01, for stepwise regression model: F = 8.828; p < 0.01, adjusted R2 = 0.091). Conclusion. Left ventricular arrhythmias are frequent in patients with lower decrease of blood pressure during the night. There was no correlation between the degree of ventricular arrhythmias and parameters from 24-hour blood pressure monitoring and a five-year prognosis in the patients with arterial hypertension and LVH. A bad five-year follow-up outcome of hypertensive disease depends on left ventricular mass index.

  • 关键词:arrhythmia; heart ventricles; blood pressure; hypertension; hypertrophy; left ventricular; prognosis
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