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标题：Leptin and Adiponectin in the HIV Associated Metabolic Syndrome: Physiologic and Therapeutic Implications
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作者：Sotirios Tsiodras ; Christos Mantzoros
期刊名称：American Journal of Infectious Diseases
印刷版ISSN：1553-6203
出版年度：2006
卷号：2
期号：3
页码：141-152
DOI：10.3844/ajidsp.2006.141.152
语种：English
出版社：Science Publications
摘要：Leptin and adiponectin represent two newly discovered adipose tissue derived hormones with important roles in energy homeostasis and insulin resistance. Their interrelations with the manifestations of the HIV associated metabolic syndrome and specific somatomorphic changes i.e. fat redistribution is reviewed. A synopsis of published studies is presented and the potential role of leptin and adiponectin is discussed. We have described an association of the HIV metabolic syndrome with a state of reduced insulin sensitivity due to adiponectin deficiency. The metabolic syndrome is also accompanied by leptin deficiency in lipoatrophic subjects and possibly by a leptin resistance state in lipohypertrophic patients. Adiponectin and / or leptin therapy in a manner similar to other leptin deficiency states may assist in the future management of such patients.
关键词：HIV; adipokine; adipocytokines; adiponectin; metabolic syndrome; insulin resistance