文章基本信息

标题：Passive Transfer of HIV-1 Antibodies and Drug Resistant Virus during a Health Care Worker Accident: Implications for HCW Post-Exposure Management
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作者：Carlos Fernando De Oliveira ; Ricardo Sobhie Diaz ; Abdallah Harmache 等
期刊名称：American Journal of Infectious Diseases
印刷版ISSN：1553-6203
出版年度：2008
卷号：4
期号：4
页码：244-256
DOI：10.3844/ajidsp.2008.244.256
语种：English
出版社：Science Publications
摘要：Problem statement: We studied in detail a case in which a nurse caring for an HIV-infected child suffered a deep-laceration accident with contaminated blood. Approach: The patient had been treated with zidovudine (ZDV) and the nurse became infected despite prophylactic use of ZDV initiated 2 h after the accident. A reactive anti-HIV-1/2 EIA and an indeterminate western blot (gp120/160 reactivity) were obtained from the nurse on the day of the accident, suggesting pre-exposure infection. However, a negative western blot and positive DNA PCR were documented 10 days after the accident and seroconversion occurred an additional two weeks later. Results: Phylogenetic analyses of HIV-1 tat and C2-C4-gp120 env regions confirmed that the nurse infected by two different HIV-1 strains present in the child. Strains present in both subjects revealed multi-nucleoside resistant HIV-1. Dilutional serological studies using 10 HIV-infected patients
关键词：HIV-1; passive transfer of antibodies; health care work accident; bottleneck; transmission of resistant HIV-1