文章基本信息

标题：Immunopathogenesis of Dengue Hemorrhagic Fever
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作者：Huan-Yao Lei ; Kao-Jean Huang ; Yee-Shin Lin 等
期刊名称：American Journal of Infectious Diseases
印刷版ISSN：1553-6203
出版年度：2008
卷号：4
期号：1
页码：1-9
DOI：10.3844/ajidsp.2008.1.9
语种：English
出版社：Science Publications
摘要：Dengue virus infection causes Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) whose pathogeneses were not clearly understood. A new hypothesis of immunopathogenesis is proposed for the development of the DHF/DSS. An aberrant immune over-activation after dengue virus infection not only impair the immune response to clear the virus, but also result in overproduction of cytokines that affect monocytes, endothelial cells, and hepatocytes, as well as the abnormal production of autoantibodies to platelet and endothelial cells. A molecular mimicry occurs between platelets/endothelial cells and dengue virus antigens. Platelets and endothelial cells are bound by the cross-reactive anti-dengue virus antibodies such as anti-NS1 or anti-prM antibodies. The IFN-γ activated macrophage would phagocytosize the osponized targets. Dengue virus-induced vasculopathy and coagulopathy are involved in the pathogenesis of hemorrhage, and the unbalance between coagulation and fibrinolysis activation increases the likelihood of severe hemorrhage in DHF/DSS. This theory of transient hemophagocytic activity in immunopathogenesis of DHF/DSS can account for specific characteristics of clinical, pathologic, and epidemiological observations in dengue virus infection.
关键词：Dengue virus; ADE; autoantibody; macrophage