文章基本信息

标题：The Flavonoid, Quercetin, Inhibits HIV-1 Infection in Normal Peripheral Blood Mononuclear Cells
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作者：Madhavan P.N. Nair ; Zainulabedin M. Saiyed ; Nimisha H. Gandhi 等
期刊名称：American Journal of Infectious Diseases
印刷版ISSN：1553-6203
出版年度：2009
卷号：5
期号：2
页码：135-141
DOI：10.3844/ajidsp.2009.135.141
语种：English
出版社：Science Publications
摘要：Problem statement: Flavonoids and related polyphenols, have been known to possess cardioprotective, anti-tumor, anti-inflammatory, anti-allergic and anti-viral activities. Previous studies have shown that flavonoid, quercetin significantly downregulates expression of pro-inflammatory cytokines in cultured cells via modulation of NFκB and p38MAPK signaling pathways. In the current study, we hypothesize that quercetin exerts anti-HIV activity by differential modulation of pro-and anti-inflammatory cytokine expression in normal PBMCs. Approach: Cultures of PBMC received either different concentrations of quercetin (1-50
关键词：Quercetin; anti-HIV; inflammatory cytokines