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标题：In vitro and In vivo Antioxidant Activity of Aphanamixis polystachya Bark
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作者：Alluri V. Krishnaraju ; Chirravuri V. Rao ; Tayi V. N. Rao 等
期刊名称：American Journal of Infectious Diseases
印刷版ISSN：1553-6203
出版年度：2009
卷号：5
期号：2
页码：60-67
DOI：10.3844/ajidsp.2009.60.67
语种：English
出版社：Science Publications
摘要：Problem statement: Free radical stress leads to tissue injury and progression of disease conditions such as arthritis, hemorrhagic shock, atherosclerosis, diabetes, hepatic injury, aging and ischemia, reperfusion injury of many tissues, gastritis, tumor promotion, neurodegenerative diseases and carcinogenesis. Safer antioxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders. Approach: Many plants possess antioxidant ingredients that provided efficacy by additive or synergistic activities. A. polystachya bark was a strong astringent, used for the treatment of liver and spleen diseases, rheumatism and tumors. Antioxidant activity of the crude extracts of bark of A. polystachya were assessed using NBT, DPPH, ABTS and FRAP assays. The potent fraction (AP-110/82C) was tested for in vivo efficacy Results: The methanol, aqueous methanol and water extracts exhibited potent antioxidant activity compared to known antioxidants. In vivo studies on potent fraction AP-110/82C demonstrated dose dependent reduction in hepatic malondialdehyde (320.6, 269.3 and 373.69
关键词：Aphanamixis polystachya; antioxidant; MDA; glutathione; catalase