文章基本信息

标题：Innovative non-animal testing strategies for reproductive toxicology: the contribution of Italian partners within the EU project ReProTect
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作者：Stefano Lorenzetti(a) ; Ilaria Altieri(a) ; Sabina Arabi(b) 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2011
卷号：47
期号：04
出版社：Editrice Kurtis Srl
摘要：Reproductive toxicity, with its many targets and mechanisms, is a complex area of toxicology; thus, the screening and identification of reproductive toxicants is a main scientific challenge for the safety assessment of chemicals, including the European Regulation on Chemicals (REACH). Regulatory agencies recommend the implementation of the 3Rs principle (refinement, reduction, replacement) as well as of intelligent testing strategies, through the development of in vitro methods and the use of mechanistic information in the hazard identification and characterization steps of the risk assessment process. The EU Integrated Project ReProTect (6th Framework Programme) implemented an array of in vitro tests to study different building blocks of the mammalian reproductive cycle: methodological developments and results on male and female germ cells, prostate and placenta are presented.
关键词：alternative methods, male and female germ cells, prostate, placenta, REACH.