文章基本信息

标题：Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid
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作者：Khashayarsha Khazaie ; Mojgan Zadeh ; Mohammad W. Khan 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2012
卷号：109
期号：26
页码：10462-10467
DOI：10.1073/pnas.1207230109
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：An imbalance of commensal bacteria and their gene products underlies mucosal and, in particular, gastrointestinal inflammation and a predisposition to cancer. Lactobacillus species have received considerable attention as examples of beneficial microbiota. We have reported previously that deletion of the phosphoglycerol transferase gene that is responsible for lipoteichoic acid (LTA) biosynthesis in Lactobacillus acidophilus (NCK2025) rendered this bacterium able to significantly protect mice against induced colitis when delivered orally. Here we report that oral treatment with LTA-deficient NCK2025 normalizes innate and adaptive pathogenic immune responses and causes regression of established colonic polyps. This study reveals the proinflammatory role of LTA and the ability of LTA-deficient L. acidophilus to regulate inflammation and protect against colonic polyposis in a unique mouse model.
关键词：dendritic cells ; regulatory T cells ; anti-inflammatory