文章基本信息

标题：The role of host population heterogeneity in the evolution of virulence
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作者：Andrea Pugliese
期刊名称：Journal of Biological Dynamics
印刷版ISSN：1751-3758
电子版ISSN：1751-3766
出版年度：2011
卷号：5
期号：2
页码：104-119
DOI：10.1080/17513758.2010.519404
出版社：Taylor & Francis
摘要：Formulae display: ? Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. I examine here the effects of host heterogeneity in the growth of immune response on the evolution and co-evolution of virulence. The analysis is based on an extension of the ‘nested model’ by Gilchrist and Sasaki [ Modeling host-parasite coevolution , J. Theor. Biol. 218 (2002), pp. 289–308]; the criteria for host and parasite evolution, in the paradigm of adaptive dynamics, for that model are derived in generality. Host heterogeneity is assumed to be fixed at birth according to a lognormal distribution or to the presence of two discrete types. In both cases, it is found that host heterogeneity determines a dramatic decrease in pathogen virulence, since pathogens will tune to the ‘weakest’ hosts. Finally we clarify how contrasting results present in the literature are due to different modelling assumptions.
关键词：evolution of virulence; host heterogeneity; host–pathogen coevolution; pathogen-immune dynamics