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  • 标题:Dietary Calcium and Dairy Modulation of Oxidative Stress and Mortality in aP2-Agouti and Wild-type Mice
  • 本地全文:下载
  • 作者:Antje Bruckbauer ; Michael B. Zemel
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2009
  • 卷号:1
  • 期号:1
  • 页码:50-70
  • 出版社:MDPI Publishing
  • 摘要:Abstract: Oxidative and inflammatory stress have been implicated as major contributors to the aging process. Dietary Ca reduced both factors in short-term interventions, while milk exerted a greater effect than supplemental Ca. In this work, we examined the effects of life-long supplemental and dairy calcium on lifespan and life-span related biomarkers in aP2-agouti transgenic (model of diet-induced obesity) and wild-type mice fed obesigenic diets until their death. These data demonstrate that dairy Ca exerts sustained effects resulting in attenuated adiposity, protection against age-related muscle loss and reduction of oxidative and inflammatory stress in both mouse strains. Although these effects did not alter maximum lifespan, they did suppress early mortality in wild-type mice, but not in aP2-agouti transgenic mice.
  • 关键词:aging; lifespan; oxidative stress; inflammatory stress; dietary calcium; dairy
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