文章基本信息

标题：Synapse turnover: a mechanism for acquiring synaptic specificity
本地全文：下载
作者：R R Ruffolo ; G S Eisenbarth ; J M Thompson 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1978
卷号：75
期号：5
页码：2281-2285
DOI：10.1073/pnas.75.5.2281
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Neurons are generated in chick retina that are able to form synapses with striated muscle cells for only a brief period during embryonic development. The ability to form synapses is lost with a half-life of 21 hr. Retina neuron-myotube synapses form rapidly but soon are terminated. Chick embryo spinal cord neurons also form synapses with muscle cells for only a limited time during development, but these synapses are long lived. These results show that different classes of synapses turn over at different rates and suggest that part of the specificity of synaptic circuits may be acquired during development by a process of selection based on synapse termination rates.