文章基本信息

标题：Structural implications of sequence variability in immunoglobulins
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作者：E A Padlan
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1977
卷号：74
期号：6
页码：2551-2555
DOI：10.1073/pnas.74.6.2551
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Immunoglobulin sequences were compared by using a technique that takes into account the dissimilarity in physicochemical properties of amino acids. Exterior residues showed greater structural variability than interior residues. High structural variability was found at positions known from crystallographic studies to be involved in hapten binding.