文章基本信息

标题：Pineal protein phosphorylation during serotonin N-acetyltransferase induction
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作者：K E Winters ; J J Morrissey ; P J Loos 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1977
卷号：74
期号：5
页码：1928-1931
DOI：10.1073/pnas.74.5.1928
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The activity of soluble protein kinase (ATP:protein phosphotransferase,EC 2.7.1.37 ) and pattern of nuclear protein phosphorylation was monitored in cultured rat pineal glands during the induction of serotonin N-acetyltransferase (acetyl-CoA:serotonin N-acetyltransferase;EC 2.3.1.5 )by l-isoproterenol. A nuclear protein appears to be phosphorylated during the early stages of enzyme induction but is not phosphorylated at later stages of induction. This correlates well with the need for RNA synthesis associated with the induction process. The nuclear protein was also phosphorylated when the pineal glands were treated with dibutyryl 3':5'-cyclic AMP. The soluble protein kinase activity appeared to decline during mid-to-late stages of enzyme induction, but there was no concomitant increase in the particulate protein kinase activity.