文章基本信息

标题：Dichloromethane as an antisickling agent in sickle cell hemoglobin
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作者：B P Schoenborn
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1976
卷号：73
期号：11
页码：4195-4199
DOI：10.1073/pnas.73.11.4195
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Microscopic studies of red cells from homozygous sickle cell patients show that dichloromethane does prevent sickle cell formation in vitro and does cause reversion of sickled cells to normal after exposure to dichloromethane. X-ray structural analysis of human deoxyhemoglobin crystals exposed to dichloromethane shows four unique binding sites. Arguments are presented to suggest that the binding site close to tryptophan 14alpha prevents the formation of helical polymers, i.e., prevent sickling.