文章基本信息

标题：Tolerance and dependence evoked by an endogenous opiate peptide
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作者：A Lampert ; M Nirenberg ; W A Klee 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1976
卷号：73
期号：9
页码：3165-3167
DOI：10.1073/pnas.73.9.3165
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Incubation of neuroblastoma X glioma hybrid cells for 12-97 hr with methionine-enkephalin results in an increase in adenylate cyclase activity [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1 ] that is mediated by the opiate receptor. The results show that cells become tolerant to, and dependent upon, enkephalin.