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  • 标题:Defective thymine dimer excision by cell-free extracts of xeroderma pigmentosum cells
  • 本地全文:下载
  • 作者:K Mortelmans ; E C Friedberg ; H Slor
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1976
  • 卷号:73
  • 期号:8
  • 页码:2757-2761
  • DOI:10.1073/pnas.73.8.2757
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Crude extracts of normal human diploid fibroblasts and of human peripheral blood lymphocytes excise thymine dimers from purified ultraviolet-irradiated DNA, or from the DNA presumably present as chromatin in unfractionated cell-free preparations of cells that had been labeled with [3H]thymidine. Extracts of xeroderma pigmentosum cells from complementation groups A, C, and D also excise thymine dimers from purified DNA, but extracts of group A cells do not excise dimers from the DNA of radioactively labeled unfractionated cell-free preparations.
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