文章基本信息

标题：Role of a peptidase in phagocyte chemotaxis
本地全文：下载
作者：S Aswanikumar ; E Schiffmann ; B A Corcoran 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1976
卷号：73
期号：7
页码：2439-2442
DOI：10.1073/pnas.73.7.2439
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The potencies of N-formylmethionyl (fMet) peptides as chemotactic agents for phagocytes are related to the rates at which they are hydrolyzed. Furthermore, chloromethyl ketones inhibit chemotaxis as do the products of hydrolysis of fMet peptides. The directed migration of cells in response to such peptides is probably brought about by the binding of the peptide to a cell receptor with subsequent cleavage by peptidase specific for aromatic residues, a process that allows the chemical gradient to be detected.