文章基本信息

标题：Purkinje cell degeneration, a new neurological mutation in the mouse
本地全文：下载
作者：R J Mullen ; E M Eicher ; R L Sidman 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1976
卷号：73
期号：1
页码：208-212
DOI：10.1073/pnas.73.1.208
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A new autosomal recessive mouse mutation, Purkinje cell degeneration (pcd), is described. Mutants exhibit a moderate ataxia beginning at 3 to 4 weeks of age. The ataxia results from postnatal degeneration of virtually all cerebellar Purkinje cells beginning around 15 to 18 days of age and progressing rapidly over the next 2 weeks. In addition to the cerebellar disease there is slow progressive degeneration in the retina (photoreceptor cells) and olfactory bulb. Also, adult males have abnormal sperm.