文章基本信息

标题：Prevention of viral-chemical co-carcinogenesis in vitro by type-specific anti-viral antibody
本地全文：下载
作者：P J Price ; T M Bellew ; M P King 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1976
卷号：73
期号：1
页码：152-155
DOI：10.1073/pnas.73.1.152
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Low passage Fischer rat embryo cultures, which are normally very resistant to transformation by 3-methylcholanthrene but are highly susceptible when chronically infected with the Rauscher murine leukemia virus, were completely protected from transformation by methylcholanthrene when treated with neutralizing antibody specific for the leukemia virus prior to and during treatment with methylcholanthrene. Sister cultures were not protected by neutralizing antibody specific for the B-tropic radiation leukemia virus. This demonstrates clearly a definite type specific role for Rauscher murine leukemia virus in the 2-methylcholanthrene transformation system in rat cells.