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标题：Effect of hypothalamic deafferentation on thyrotropin-releasing hormone levels in rat brain
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作者：M J Brownstein ; R D Utiger ; M Palkovits 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1975
卷号：72
期号：10
页码：4177-4179
DOI：10.1073/pnas.72.10.4177
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The medial basal hypothalamus was isolated from the remainder of the brain of the rat using a Halasz knife. Ten to 14 days after the surgical procedure the concentration of thyrotropin-releasing hormone within the island of hypothalamic tissue was 76% lower than in tissue from sham-operated control rats. Thus, much of the thyrotropin-releasing hormone that is normally present in the medial basal hypothalamus may be synthesized by cells outside of this region. There were no reductions in hormone levels in regions outside of the hypothalamic island after the surgical procedure. Extrahypothalamic thyrotropin-releasing hormone does not appear to be produced by hypothalamic neurosecretory cells.