文章基本信息

标题：Evolutionary and structural influences on light chain constant (CL) region of human and mouse immunoglobulins
本地全文：下载
作者：E A Kabat ; E A Padlan ; D R Davies 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1975
卷号：72
期号：7
页码：2785-2788
DOI：10.1073/pnas.72.7.2785
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A comparison of five constant region sequences of human and mouse k and lambda immunoglobulin chains has been undertaken in order to reveal sequence homologies and evolutionary relationships. Simultaneously, a comparison with the three-dimensional structure of one mouse k-chain (McPC 603) has suggested structural reasons why many of the residues are invariant or conserved along k versus lambda lines. There are a number of residues that have remained invariant despite exposed positions for reasons that do not apppear to be connected with the folding of the CL domain.