文章基本信息

标题：A structural change of the plasma membrane induced by oncogenic viruses: quantitative studies with the freeze-fracture technique
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作者：G Torpier ; L Montagnier ; J M Biquard 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1975
卷号：72
期号：5
页码：1695-1698
DOI：10.1073/pnas.72.5.1695
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：In BHK21 hamster cells a significant increase in density of intramembranous particles occurs in freeze-fractured plasma membranes after transformation by hamster sarcoma and polyoma viruses. A similar change has been observed in chick embryo cells infected and transformed by a mutant of Rous sarcoma virus thermosensitive for transformation, at both permissive and nonpermissive temperatures. There is also an increase in particle density in chick cells infected with the Rous-associated avian leukosis virus type 1. The newly appeared particles may represent the insertion of new proteins in hydrophobic regions of plasma membrane, in response to the action of oncogenic viruses.