文章基本信息

标题：Patients with Ehlers-Danlos syndrome type IV lack type III collagen
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作者：F M Pope ; G R Martin ; J R Lichtenstein 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1975
卷号：72
期号：4
页码：1314-1316
DOI：10.1073/pnas.72.4.1314
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：One of the genetically distinct collagens (type III) normally found in skin, aorta, and intestine is missing from the tissues of patients with the Ehlers-Danlos syndrome type IV. While skin fibroblasts from other individuals synthesize both types I and III collagen. Ehlers-Danlos syndrome IV cells synthesize only type I. These results suggest that the fragile skin, blood vessels, and intestines of Ehlers-Danlos syndrome IV patients result from an absence of type III collagen.