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  • 标题:Variability of three-dimensional structure in immunoglobulins
  • 本地全文:下载
  • 作者:E A Padlan ; D R Davies
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1975
  • 卷号:72
  • 期号:3
  • 页码:819-823
  • DOI:10.1073/pnas.72.3.819
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:A comparison of various variable immunoglobulin domains demonstrates that structural variability parallels the observed frequency of amino-acid substitutions. The similarity of the structural frameworks is in good agreement with the evolutionary relationships of the chains as derived from sequence analysis.
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