文章基本信息

标题：Material Isolated from Normal and Variant Human Liver that Immunologically Crossreacts with Alpha1-Antitrypsin
本地全文：下载
作者：Shoji Matsubara ; Akira Yoshida ; Jack Lieberman 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：9
页码：3334-3337
DOI：10.1073/pnas.71.9.3334
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A material that strongly reacts with antibodies against alpha1-antitrypsin, but has little trypsin inhibitory capacity, has been isolated and purified to homogeneity from human liver. The molecular weight of the crossreacting material is about 18,000, which is significantly lower than that of serum alpha1-antitrypsin. The material isolated from the liver of a homozygous variant subject (ZZ) with alpha1-antitrypsin deficiency is readily distinguished by electrophoresis from the material extracted from a normal (MM) subject. The tissues from a heterozygous variant subject (MZ) contain the two components. The immunologically crossreacting material is presumably synthesized by the gene that codes for alpha1-antitrypsin.
关键词：pulmonary emphysema ; liver cirrhosis ; trypsin inhibition ; antitrypsin deficiency