文章基本信息

标题：Diffusion in Polymer Gel Implants
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作者：B. K. Davis
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：8
页码：3120-3123
DOI：10.1073/pnas.71.8.3120
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Crosslinked polyacrylamide and polyvinylpyrrolidone gels have been used to subcutaneously implant 125I-labeled immunoglobulin, 125I-labeled luteinizing hormone, 125I-labeled bovine serum albumin, 125I-labeled insulin, [3H]prostaglandin F2[α], and Na125I into hamsters. From the rates of absorption of the solutes, their diffusion coefficients were determined. The diffusion coefficients showed a logarithmic dependence on implant polymer concentration and solute molecular weight. Release of the solutes from gel preparations incubated 10 mM phosphate buffer (pH 7.2) at 37{degrees} revealed a similar relationship between solute diffusion coefficient, molecular weight, and the concentration of polymer. A general equation was derived that gives the expected diffusion coefficient of a substance in a polymer gel from its molecular weight, diffusion coefficient in solvent, and polymer concentration of the gel.
关键词：¹²⁵I-solutes ; polyacrylamide and polyvinylpyrrolidone gels ; hamsters ; retarded release