文章基本信息

标题：Procollagen: Intermediate Forms Containing Several Types of Peptide Chains and Non-Collagen Peptide Extensions at NH2 and COOH Ends
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作者：Marvin L. Tanzer ; Robert L. Church ; James A. Yaeger 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：8
页码：3009-3013
DOI：10.1073/pnas.71.8.3009
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A population of procollagen molecules has been isolated from the culture medium of a clonal line of calf dermatosparactic cells and shown to have the amino-acid composition, physical properties, and molecular structure consistent with collagen precursors. Although this procollagen population shares immunologic determinants with the procollagen obtained from dermatosparactic skin, it differs from the latter in aminoacid composition, in subunit properties, and by its content of both amino and carboxyl terminal non-collagen peptide appendages. We propose that the cell culture procollagen contains earlier biosynthetic forms of dermatosparactic procollagen.
关键词：acidic and basic polypeptides ; dermatosparactic cells