文章基本信息

标题：Role of the Polyadenylate Segment in the Translation of Globin Messenger RNA in Xenopus Oocytes
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作者：G. Huez ; G. Marbaix ; E. Hubert 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：8
页码：3143-3146
DOI：10.1073/pnas.71.8.3143
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The translations of native messenger RNA for rabbit globin and that of poly(A)-free globin messenger RNA have been compared after injection into Xenopus oocytes. The initial rate of translation of poly(A)-free mRNA is close to that found with intact mRNA. However, at longer incubation periods, the rate of globin synthesis with poly(A)-free mRNA is considerably lower than with native mRNA. Similar differences in the template activity of the two mRNA preparations were found with a cell-free extract of Krebs II ascites tumor. It is concluded that the presence of the 3' poly(A)-rich sequence in mRNA is required to ensure high functional stability.
关键词：poly(A) ; functional stability ; Krebs II ascites tumor