文章基本信息

标题：On Some Principles Governing Molecular Evolution
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作者：Motoo Kimura ; Tomoko Ohta
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：7
页码：2848-2852
DOI：10.1073/pnas.71.7.2848
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The following five principles were deduced from the accumulated evidence on molecular evolution and theoretical considerations of the population dynamics of mutant substitutions: (i) for each protein, the rate of evolution in terms of amino acid substitutions is approximately constant/site per year for various lines, as long as the function and tertiary structure of the molecule remain essentially unaltered. (ii) Functionally less important molecules or parts of a molecule evolve (in terms of mutant substitutions) faster than more important ones. (iii) Those mutant substitutions that disrupt less the existing structure and function of a molecule (conservative substitutions) occur more frequently in evolution than more disruptive ones. (iv) Gene duplication must always precede the emergence of a gene having a new function. (v) Selective elimination of definitely deleterious mutants and random fixation of selectively neutral or very slightly deleterious mutants occur far more frequently in evolution than positive Darwinian selection of definitely advantageous mutants.
关键词：population genetics ; mutational pressure ; negative selection ; random drift