文章基本信息

标题：Prolongation of the Life-Span in Mice Adapted to Large Amounts of L-Dopa
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作者：George C. Cotzias ; Samuel T. Miller ; Alexander R. Nicholson 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：6
页码：2466-2469
DOI：10.1073/pnas.71.6.2466
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Various concentrations of L-dopa (levodopa, L-3,4-dihydroxyphenylalanine) were incorporated in the diets of young male Swiss albino mice, and the highest concentrations to which these mice became adapted within 3 weeks were determined. One such concentration administered indefinitely eventually induced a youthful appearance, a significantly prolonged life-span, but also corneal opacities compatible with traumatic or chemical keratitis.
关键词：adaptation ; body weight ; levodopa ; corneal opacities