文章基本信息

标题：Alteration of Vein Cyclic 3′:5′ Nucleotide Concentrations During Changes in Contractility
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作者：Earl W. Dunham ; Mari K. Haddox ; Nelson D. Goldberg 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：3
页码：815-819
DOI：10.1073/pnas.71.3.815
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The relative changes in vascular tissue levels of cyclic 3':5'-guanosine monophosphate (cGMP) and cyclic 3':5'-adenosine monophosphate (cAMP) were determined in bovine and canine vein strips that were quickfrozen during changes in contractility elicited by prostaglandins (PG) or isoproterenol. Prostaglandin F2[α]-induced venoconstriction was associated with increased vascular tissue levels of cGMP and increased ratios of cGMP to cAMP concentrations, but no consistent qualitative change in cAMP levels. In contrast, vein cAMP concentrations were increased during administration of the vasodilators PGE2 and isoproterenol. The results suggest possible opposing roles for the two cyclic nucleotides in vasomotion.
关键词：vascular smooth muscle ; prostaglandins F_2α and E₂ ; cyclic GMP ; cyclic AMP ; isoproterenol