文章基本信息

标题：A Human Leukemia Cell with Both B and T Cell Surface Receptors
本地全文：下载
作者：E. Shevach ; R. Edelson ; M. Frank 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：3
页码：863-866
DOI：10.1073/pnas.71.3.863
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Bone-marrow-derived (B) and thymus-derived (T) lymphocytes can be distinguished by the presence of a number of receptors and differentiation antigens. The presence of these markers has facilitated the identification and characterization of the mononuclear cells in a number of animal and human lymphoid malignancies. We describe here the immunological properties of human leukemia cells that are highly unusual, since they simultaneously bear the receptor for sheep erythrocytes characteristic of human T lymphocytes and the receptor for antigen-antibody-complement complexes characteristic of human B lymphocytes. A small number (about 2%) of normal human lymphocytes bearing both of these receptors was also identified.
关键词：lymphocytic leukemia ; Sezary's syndrome