文章基本信息

标题：Primate RNA Tumor Virus-Like DNA Synthesized Endogenously by RNA-Dependent DNA Polymerase in Virus-Like Particles from Fresh Human Acute Leukemic Blood Cells
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作者：R. C. Gallo ; N. R. Miller ; W. C. Saxinger 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：11
页码：3219-3224
DOI：10.1073/pnas.70.11.3219
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A particle of discrete biochemical composition was purified from fresh, unfrozen peripheral blood leukocytes of human patients with acute myeloblastic leukemia. This particle endogenously synthesized DNA by use of an RNA primer and template. About half of the DNA sequences synthesized in the presence of actinomycin D hybridized to RNA isolated from type-C sarcoma viruses of primates or mice; lower annealing values were obtained with RNA isolated from other sarcoma or leukemia viruses. The results confirm and extend previous results from molecular hybridization experiments related to the existence in human leukemia of components of RNA tumor viruses.
关键词：leukemia ; molecular hybridization ; type-C sarcoma virus