文章基本信息

标题：A Theory of the Epigenesis of Neuronal Networks by Selective Stabilization of Synapses
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作者：Jean-Pierre Changeux ; Philippe Courrége ; Antoine Danchin 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：10
页码：2974-2978
DOI：10.1073/pnas.70.10.2974
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A formalism is introduced to represent the connective organization of an evolving neuronal network and the effects of environment on this organization by stabilization or degeneration of labile synapses associated with functioning. Learning, or the acquisition of an associative property, is related to a characteristic variability of the connective organization: the interaction of the environment with the genetic program is printed as a particular pattern of such organization through neuronal functioning. An application of the theory to the development of the neuromuscular junction is proposed and the basic selective aspect of learning emphasized.
关键词：control theory ; graph theory ; learning ; synaptic plasticity ; neuromuscular junction