文章基本信息

标题：Structural Comparison of Ectopic and Normal Placental Alkaline Phosphatase
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作者：Patricia J. Greene ; Howard H. Sussman
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：10
页码：2936-2940
DOI：10.1073/pnas.70.10.2936
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：An alkaline phosphatase immunochemically similar to placental alkaline phosphatase (EC 3.1.3.1 ) was purified from liver metastases of a giant-cell carcinoma of the lung. Some properties of its physical and chemical structure were determined and compared to those of purified placental alkaline phosphatase. The purified tumor phosphatase and the placental phosphatase were similar with regard to the following properties: (1) NH2-terminal sequence, (2) peptide map, (3) subunit molecular weight, and (4) isoelectric point. The physical properties and NH2-terminal sequence of alkaline phosphatase isoenzyme of liver differed from the placental and the tumor enzyme. The data from the present study strongly support the hypothesis that the tumor and the placental alkaline phosphatases are products of the same gene.
关键词：NH₂-terminal sequence ; peptide map ; tumor protein