文章基本信息

标题：Pleiotypic Control by Cyclic AMP: Interaction with Cyclic GMP and Possible Role of Microtubules
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作者：Raphael Kram ; Gordon M. Tomkins
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：6
页码：1659-1663
DOI：10.1073/pnas.70.6.1659
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Previous studies have shown that exogenous dibutyryl cyclic AMP inhibits the uptake of uridine, leucine, and 2-deoxyglucose by cultured mouse fibroblasts. 3':5'-cyclic GMP is shown here to counteract these inhibitory effects as well as the inhibition of precursor transport and leucine incorporation into proteins produced by prostaglandin E1. We conclude, therefore, that cyclic GMP antagonizes the "pleiotypic" effects of cyclic AMP in these cells. Colcemid and vinblastine, but not cytochalasin B, reverse the transport inhibition caused by cyclic AMP without affecting the intracellular concentrations of cyclic AMP. These results suggest the possibility that cyclic AMP regulates the membrane transport of certain substrates by influencing the organization of microtubules.
关键词：prostaglandins ; colcemid ; vinblastine ; membrane transport