文章基本信息

标题：Inhibition of Murine Leukemia Virus Replication by Poly(vinyluracil) and Poly(vinyladenine)
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作者：Paula M. Pitha ; Natalie M. Teich ; Douglas R. Lowy 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：4
页码：1204-1208
DOI：10.1073/pnas.70.4.1204
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Poly(1-vinyluracil) and poly(9-vinyladenine), as well as the corresponding polynucleotides poly(uridylate) and poly(adenylate), inhibit acute murine leukemia virus infection in mouse-embryo cells, but they do not significantly inhibit the replication of Sindbis and vesicular stomatitis viruses. The polymers were most effective as inhibitors when added during an early stage of virus replication. Effects of vinyl polymers on the RNA-dependent DNA polymerase from the virions of murine leukemia virus were also observed.
关键词：vesicular stomatitis virus ; Sindbis virus ; RNA-dependent DNA polymerase ; viral chemotherapy