文章基本信息

标题：Human Anti-IgM Iso-Antibodies: Detection of IgM Allotypic Markers
本地全文：下载
作者：J. Vivian Wells ; Jan F. Bleumers ; H. Hugh Fudenberg 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：3
页码：827-829
DOI：10.1073/pnas.70.3.827
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：IgG class antibodies against human IgM were detected in a human subject up to a titer of 1:1024 against 5 of a group of 23 monoclonal Waldenstrom macroglobulins. Inhibition studies confirmed at least one antigenic determinant shared by the 5 IgMs. The determinant was present on the {micro} chain but required tertiary structure for its full expression. Inhibition of the reaction between the antibodies to IgM and erythrocytes coated with 2 of the 5 IgMs was obtained at titers of 1:2 to 1:16 with 51.0% of 300 normal sera (85.2% of sera from 122 Caucasian, 26.1% of sera from 23 Negro, and 27.7% of sera from 155 Japanese individuals). This inhibition was independent of the serum IgM concentration. Family studies indicated that the determinant was inherited according to basic Mendelian laws and appears to be the first allotypic marker on human serum IgM. We have designated it Mm 1.
关键词：IgG ; Waldenström macroglobulins ; allotypic marker