文章基本信息

标题：Regulation of Macromolecular Biosynthesis in a Mutant of Escherichia coli Defective in Membrane Phospholipid Biosynthesis
本地全文：下载
作者：Michael Glaser ; William H. Bayer ; Robert 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：2
页码：385-389
DOI：10.1073/pnas.70.2.385
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Nucleic acid and protein synthesis were studied in temperature-sensitive mutants defective in phospholipid synthesis. The defect is due to a single mutation in glycerol 3-phosphate acyltransferase (EC 2.3.1.15 ). The results show that at the restrictive temperature not only does phospholipid synthesis cease, but DNA, RNA, and protein synthesis also cease. Active transport continues, however, indicating that the cells do not become leaky or lose their energy supply. These results suggest that phospholipid synthesis is coupled to DNA, RNA, and protein synthesis.
关键词：temperature-sensitive glycerol 3-phosphate acyltransferase ; protein ; active transport