文章基本信息

标题：Changes in Alkaline Ribonuclease Activity During Compensatory Renal Growth
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作者：Pedro Rosso ; James Diggs ; Myron Winick 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：1
页码：169-172
DOI：10.1073/pnas.70.1.169
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Unilateral nephrectomy in rats produces an increase in ribonuclease activity in both nuclear and cytoplasmic fractions of the contralateral kidney. The timing of this increase and the changes in the proportion of free activity to protein-bound activity are different in each fraction. A peak in inhibitor-bound ribonuclease, suggesting a higher amount of inhibitor, was found in the cytoplasmic fraction before the increase in RNA/DNA ratio. Ninety-six hours after the operation, ribonuclease was still significantly increased in both the nuclear and cytoplasmic fractions. The inhibitor-bound activity was increased in proportion to cellular RNA, maintaining a ribonuclease activity per {micro}g of RNA similar to the controls.